DIAGNOSTICS Past, present & the next frontier

ExoLiteTM

Measure the immune activity by quantifying the microRNA of the immune cell exosome in the blood.

Use total immune cells to check the wide range of immune activations in the body

Immuno cellular activity test

Pre-examination that is more basic than diagnosis of disease, diagnosis of cancer

The overall health status can be checked in a simple way.

Use as a prognosis test after treatment as well as a pre-examination.

Coventional immune cell vitalization method

Coventional immune cell vitalization method
Flow cytometric Assay Chromium51 Release Assay Measurement of vitalization from other companies ExoLite
Object Counting NK Cell Measuring NK cell toxicity Measing vitalization of NK cell Measuring all groups of immune cell activation which existed in blood (NK, Mq, Treg cell, etc)
Analyte CD3, CD16,/56 Radioactive isotope (Chromium51) IFN-γ secereted from NK cell Multi miRNA controls immune activation
Sample PBMC PBMC Whole blood Whole blood
period 5 hours (approx.) 5~7 days (approx.) 24-48 hours (include 20-24 hours of cultivation) 4-12 hours
accuracy may differ depends on the inspector may differ depends on the inspector ELISA method
requries basic education
less difference between inspector		 qPCR method
requires basic education
less difference between inspector
limitation Can measure the relative numbers of cell
  • -Use radioactive isotope
  • -Use cancer cell line as a target cell
  • -Complex study pocess
  • -Low reproducibility
  • -Requires more time and cost
  • -Difficult to check bulk samples
  • Cannot have representative of immunity (as it uses only NK cell)
  • Less test accuracy as single biomarker
  • Time necessary for cell incubation
 None

ExoLite kit Strength

It is prossible to confirm more accurate results by quantification with complex gene biomarkers.

Exomes in multiple immune cells are isolated and checked for a wide range of immune responses.